Vascularized tissue flaps are use to repair and reconstruct complex anatomic defects after trauma, oncologic surgery, infection, and other pathologies. The most common complication arises after venous outflow obstruction or thrombosis and can result in flap and reconstructive failure if not detected in a timely fashion. We have identified ProL1 as an early upregulated biomarker of venous ischemia and in this proposal will further characterize its expression pattern and determine if modulation of ProL1 gene expression can improve outcomes after critical venous ischemia.

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