The focus of this proposal is to assess if exercise intervention may be a useful tool for the treatment of relapsing-remitting Multiple Sclerosis. We will use an mouse model of RR-MS, PLP-induced experimental allergic encephalomyelitis (EAE), to test if treadmill exercise inhibits disease progression. We will also assess for correlates of any clinical benefit of exercise with changes in CNS resident microglia activity and peripheral adaptive immune responses.

NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.