One of the major risk factors of type 2 diabetes (T2DM) is obesity, which has become a pandemic in developed countries. We have discovered a central regulator of metabolism that is encoded in the mitochondrial genome, representing an undexplored biology with significant cellular activity. Mitochondiral peptides are an entirely novel therapeutic/preventive target of T2DM.

NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.