The focus of this project is to prove feasibility of an innovative assay to more accurately assess CFTR (CF transmembrane and conductance regulator) function in children with a positive newborn screening for Cystic Fibrosis (CF). The B – Adrenergic Sweat Rate test, recently validated in adults by Doctor Paul Quinton et al, offers a more sensitive assessment of CFTR function compared to the current gold standard sweat chloride test. These measurements will assist physicians to determine the proper level of care for each positive screen child. Additionally, it will generate more information about Hispanic CF mutations, positively impacting the health of this understudied population.

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