Muscle weakness resulting from anterior cruciate ligament (ACL) injury with surgical reconstruction preferentially affects the quadriceps muscle group and is profound and long lasting. This is of concern as quadriceps strength deficits contribute to poor function, increased risk for re-injury, and the development and progression of knee osteoarthritis, osteoporosis, and degenerative joint disease. Testosterone administration in men undergoing ACL reconstructive surgery may attenuate quadriceps atrophy, maintain strength, and reduce inflammation, optimizing rehabilitation and long-term function.

NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.