The overall goals of this pilot project are to use the Hybrid Mouse Diversity Panel and characterize the 30 classic inbred mouse strains for traits related to asthma, cancer, aging, cardiac regeneration, and other biomedically important phenotypes with high translational impact. We will then apply the phenotypic data generated from this survey in a first-pass genetic analysis to map putative regions of the genome that are associated with these traits. In combination, the results of these studies will be used towards obtaining R01-type extramural funding to characterize the remaining ~100 strains from the HMDP and carry out a full genetic analysis.

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