This project aims to vastly improve the spatio-temporal resolution, spatial coverage, reliability, and overall value of dynamic contrast enhanced (DCE) MRI scans of the brain. These scans are routinely used to image the blood vessels in the brain, delivery of blood and nutrients to the brain, and ability of nutrients to pass between blood vessels and brain. Improvements in DCE-MRI technology could enable better diagnosis and better treatment monitoring for patients with brain tumors, and may also have application in other neurological disorders such as stroke, epilepsy, and dementia, and multiple sclerosis.