This project seeks to demonstrate that RNA in maternal serum is a source of placental biomarkers. We will use RNA-seq to identify transcripts that are abundant in first-trimester serum of pregnant women and that are absent in the serum of non-pregnant women. We will perform bioinformatic analyses to profile the placental transcriptome during the first trimester of pregnancy.

NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.